Uranyl nitrate-induced acute renal failure in the rat: Micropuncture and renal hemodynamic studies
نویسندگان
چکیده
منابع مشابه
The Mechanism of Acute Renal Failure after Uranyl Nitrate ROLAND
Portions of this work were presented at the Annual Meeting of The American Federation for Clinical Research, Atlantic City, N. J., 5 May 1974. Received for publication 21 June 1974 and in revised form 18 November 1974. dose UN (0.047±0.013) and high dose (0.024±0.003 nVs/g kidney wt/mm Hg). Therefore UN decreases GFR by two mechanisms: (a) tubular damage leading to back-diffusion of solutes and...
متن کاملExperimental acute renal failure induced by uranyl nitrate in the dog.
The diminished glomerular filtration rate observed in previous studies of acute renal failure induced by uranyl nitrate has been ascribed to backflow of glomerular filtrate through necrotic tubular epithelium, since renal blood flow was essentially normal. Renal blood flow (xenon washout) and renal function were studied serially for 96 hours after the administration of uranyl nitrate (10 mg/kg,...
متن کاملGlomerular endothelial cells in uranyl nitrate-induced acute renal failure in rats.
In uranyl nitrate (UN)-induced acute renal failure (ARF) glomerular ultrafiltration coefficient (K(f)) decreases because of unknown reasons. Since transport of water across the glomerular capillary wall occurs predominantly extracellularly through the endothelial fenestrae (EF), a reduction in the diameter and/or the density of EF can reduce the extracellular filtration area and the glomerular ...
متن کاملRenal hemodynamics in uranyl acetate-induced acute renal failure of rabbits.
The role of renal hemodynamic alterations in the curtailment of renal function was studied in rabbits with uranyl acetate-induced acute renal failure. The day following the i.v. injection of uranyl acetate (2 mg/kg of body wt), renal blood flow (RBF) and clearance of creatinine (Ccr) decreased to approximately 60 and 20% of controls, respectively. Intracortical fractional flow distribution, est...
متن کاملAcute Renal Failure Studies
GFR markers Among newer GFR markers in ARF, serum cystatin C deserves evaluation since it has been shown more sensitive and accurate than serum creatinine in several settings, but has not been validated as a GFR indicator in ARF (1-2). Another endogenous marker, β2-microglobulin, has been suggested as a GFR estimate (3). Measuring tubular enzymuria could facilitate the early detection of renal ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1974
ISSN: 0085-2538
DOI: 10.1038/ki.1974.126